A Broadband Sensor Interface IC for Miniaturized Dielectric Spectroscopy From MHz to GHz
作者:Mehran Bakhshiani, Michael A. Suster, Pedram Mohseni
摘要:This paper describes a broadband biosensor interface IC as part of a miniaturized measurement platform currently under development for MHz-to-GHz dielectric spectroscopy (DS). Developed in 0.35μm 2P/4M RF CMOS, the IC measures the frequency-dependent S21 magnitude and phase of a microfabricated microfluidic dielectric sensor, when the sensor is loaded with a solution-under-test (SUT). The IC architecture implements a modified frequency response analysis (FRA) method by first down-converting the biosensor response signal from the RF excitation frequency to an intermediate frequency (IF) of 1MHz using an LNA and active mixer, followed by down-converting the IF signal to dc using a coherent detector employing IF amplification stages with programmable gain, a passive mixer driven by in-phase (I) and quadrature-phase (Q) signals, and an active-RC lowpass filter (LPF). Dielectric readings of ethanol from the biosensor interfaced with the IC at five excitation frequencies in the range of 50MHz to 2GHz are in excellent agreement ...
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